Text Box: #
Text Box: #

Synthesis of Oligosachharides

 

Research Interests

Gold-catalyzed Glycosidation Laboratory (G2L)

www.iiserpune.ac.in/~s.hotha

s.hotha@iiserpune.ac.in

+91 20 2590 8015, +91 20 2589 9790 (fax), +91 9823677254

Synthesis of oligosaccharides in our group stands on the protocols that we have developed over the last several years using gold catalysts. We can synthesize both 1,2-trans and 1,2-cis linkages of Mannopyranose in stereoselective fashion. Gold catalysis on propargyl 1,2-orthoesters results in 1,2-trans mannopyranosides with 2-O-ester moiety that can be saponified, oxidized and reduced to get the corresponding 1,2-cis mannopyranosides as shown in the synthesis of terminal tetrasaccharide cap of Leishmania donovani.

Synthesis of oligosaccharides in our group stands on the protocols that we have developed over the last several years using gold catalysts. We can synthesize both 1,2-trans and 1,2-cis linkages of Mannopyranose in stereoselective fashion. Gold catalysis on propargyl 1,2-orthoesters results in 1,2-trans mannopyranosides with 2-O-ester moiety that can be saponified, oxidized and reduced to get the corresponding 1,2-cis mannopyranosides as shown in the synthesis of terminal tetrasaccharide cap of Leishmania donovani.

Bioinspired protocols for the synthesis of a- and b- arabinofuranosides enticed us to synthesize various cell surface epitopes of Mycobacterium sp. The molecules that we are currently interested are shown below.

Solution phase Synthesis of these complex oligofuranosides is currently underway in our group. In synthesizing these epitopes we are using methods developed in our laboratory over the last several years. We are also exploring synthesis by solid phase methods for these oligosaccharides.

 

Please visit us back for the latest progress in this endeavour. 

We will be very happy to discuss further (& collaborate, if possible) if you have interest in these molecules

1

3

2