Indian Institute of Science Education and Research
Professor S. G. Srivatsan
Department of Chemistry
Wellcome Trust/DBT India Alliance Senior Fellow (2016-2022)
Dr. Homi Bhabha Road, Pashan
Srivatsan extends his sincere thanks to all the former and present members of his laboratory for their immense contribution, which has lead to national and international recognition:
1. Sun Pharma Research Award 2020 in the Pharmaceutical Sciences
2. National Prize for Research on Chemistry of Peptides and Nucleic Acids 2020 (Sponsored by CNR Rao Education Foundation)
3. Chemical Research Society of India (CRSI) Bronze medal for 2020
4. CDRI awards 2019 for Excellence in Drug Research
5. Editorial Advisory Board member of ACS Bioconjugate Chemistry
Congratulations Saddam, Pulak and coauthors for recent publications in Chemical Science and JACS.
1. Khatik, S. Y.; Sudhakar, S.; Mishra, S.; Kalia, J.; Pradeepkumar, P. I.; Srivatsan, S. G.* Probing juxtaposed G-quadruplex and hairpin motifs using a responsive nucleoside probe: a unique scaffold for chemotherapy. Chemical Science 2023.
2. Ghosh, P.; Kropp, H. M.; Betz, K.; Ludmann, S.; Diederichs, K.; Marx, A.;* Srivatsan, S. G.* Microenvironment-sensitive fluorescent nucleotide probes from benzofuran, benzothiophene, and selenophene as substrates for DNA polymerases. J. Am. Chem. Soc. 2022, 144, 10556–10569.
3. Khatik, S. Y.; Srivatsan, S. G.* Environment-sensitive nucleoside probe unravels the complex structural dynamics of i-motif DNAs. Bioconjugate Chem. 2022, 33, 1515–1526.
4. George, J. T.; Srivatsan, S. G.* Responsive fluorescent nucleotides serve as efficient substrates to probe terminal uridylyl transferase. Chem. Commun. 2020, 56, 12319−12322.
5. George, J. T.; Mohd. Azhar; Aich, M.; Sinha, D.; Ambi, U. B.; Maiti, S.;* Chakraborty, D.;* Srivatsan, S. G.* Terminal uridylyl transferase mediated site-directed access to clickable chromatin employing CRISPR-dCas9. J. Am. Chem. Soc. 2020, 142, 13954−13965.
6. Walunj, M. B.; Srivatsan, S. G.* Nucleic acid conformation influences postsynthetic Suzuki–Miyaura labeling of oligonucleotides. Bioconjugate Chem. 2020, 31, 2513–2521.
7. Manna, S.; Srivatsan, S. G.* Synthesis and enzymatic incorporation of a responsive ribonucleoside probe that enables quantitative detection of metallo-base pairs. Org. Lett. 2019, 21, 4646-4650.
8. Ashok, N.; Ishtiyaq, A.; Saddam, Y. K.; Kayarat, S.;* Srivatsan, S. G.* Probing G-quadruplex topologies and recognition concurrently in real time and 3D using a dual-app nucleoside probe. Nucl. Acid. Res. 2019, 47, 6059-6072.
9. Manna, S.; Sarkar, D.; Srivatsan, S. G.* A Dual-app nucleoside probe provides structural insights into the human telomeric overhang in live cells. J. Am. Chem. Soc. 2018, 140, 12622-12633.
10. Walunj, M. B.; Tanpure, A. A.; Srivatsan, S. G.* Posttranscriptional labeling by using Suzuki-Miyaura cross-coupling generates functional RNA probes. Nucl. Acid. Res. 2018, 46, e65.
Chemical Biology: Nucleic Acid Chemistry, Biophysics, Self-assemblies
We use physical organic concepts to develop tools to assess structure, dynamics and function of nucleic acids in cell-free and complex cellular environments. In this direction, we have initiated two research programs. One involves the development of minimally perturbing and conformation-sensitive multi-app nucleoside probes for studying nucleic acids in real time by fluorescence, in 3D by X-ray crystallography and in cells by NMR. In the second program, we establish methods to label nucleic acids with variety of functionalities by using bioorthogonal chemistry like click and metal-catalyzed reactions. In parallel, we are also interested in developing multifunctional nucleolipid conjugates that self-assemble into nanofibres, nanotubes and gels. These assemblies show aggregation-induced fluorescence, self-sorting behavior and surface-switchable properties. Our research is multidisciplinary in nature involving synthetic organic chemistry, biophysics, molecular, cell and structural biology.
Our research in youtube: https://www.youtube.com/watch?v=7CFzZjauYl8
Srivatsan interview: https://www.youtube.com/watch?v=DLV32SCIuuo
Our efforts in COVID research: https://www.youtube.com/watch?v=KarLWR3CvzQ