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Professor S. G. Srivatsan

Department of Chemistry

Wellcome Trust/DBT India Alliance Senior Fellow (2016-2022)

IISER, Pune

Dr. Homi Bhabha Road, Pashan
Pune 411008, India

Tel.: +91-20-25908086

E-mail: srivatsan@iiserpune.ac.in

Lab News

 

Congratulations Pulak Ghosh for successfully defending the PhD thesis

Congratulations Pulak Ghosh for receiving the Alexander von Humboldt postdoctoral fellowship

Srivatsan extends his sincere thanks to all the former and present members of his laboratory for their immense contribution, which has lead to national and international recognition:

1. Sun Pharma Research Award 2020 in the Pharmaceutical Sciences

2. National Prize for Research on Chemistry of Peptides and Nucleic Acids 2020 (Sponsored by CNR Rao Education Foundation)

3. Chemical Research Society of India (CRSI) Bronze medal for 2020

4. CDRI awards 2019 for Excellence in Drug Research

5. Editorial Advisory Board member of ACS Bioconjugate Chemistry

 

Recent articles

Congratulations Sarupa Roy and Saddam Khatik and coauthors for recent publications in Chemical Science and ACS Chemical Biology.

1. Roy, S.; Majee, P.; Sudhakar, S.; Mishra, S.; Kalia, J.; Pradeepkumar, P.I.;* Srivatsan, S. G.* Structural elucidation of HIV-1 G-quadruplexes in a cellular environment and their ligand binding using responsive 19F-labeled nucleoside probes. Chem. Sci. 2024, DOI:10.1039/d4sc01755b.

2. Khatik, S. Y.; Roy, S.; Srivatsan, S. G.* Synthesis and enzymatic incorporation of a dual-app nucleotide probe that reports antibiotics-induced conformational change in the bacterial ribosomal decoding site RNA. ACS Chem. Biol. 2024, 19, 687-695.

3. Pandey, A.; Roy, S.; Srivatsan, S. G.* Probing the competition between duplex, G-quadruplex and i-motif structures of the oncogenic c-Myc DNA promoter region. Chem. Asian J. 2023, e202300510.

4. Khatik, S. Y.; Sudhakar, S.; Mishra, S.; Kalia, J.; Pradeepkumar, P. I.; Srivatsan, S. G.* Probing juxtaposed G-quadruplex and hairpin motifs using a responsive nucleoside probe: a unique scaffold for chemotherapy. Chemical Science 2023, 14, 5627-5637.

5. Ghosh, P.; Kropp, H. M.; Betz, K.; Ludmann, S.; Diederichs, K.; Marx, A.;* Srivatsan, S. G.* Microenvironment-sensitive fluorescent nucleotide probes from benzofuran, benzothiophene, and selenophene as substrates for DNA polymerases. J. Am. Chem. Soc. 2022, 144, 10556-10569.

6. Khatik, S. Y.; Srivatsan, S. G.* Environment-sensitive nucleoside probe unravels the complex structural dynamics of i-motif DNAs. Bioconjugate Chem. 2022, 33, 1515-1526.

7. George, J. T.; Srivatsan, S. G.* Responsive fluorescent nucleotides serve as efficient substrates to probe terminal uridylyl transferase. Chem. Commun. 2020, 56, 12319-12322.

8. George, J. T.; Mohd. Azhar; Aich, M.; Sinha, D.; Ambi, U. B.; Maiti, S.;* Chakraborty, D.;* Srivatsan, S. G.* Terminal uridylyl transferase mediated site-directed access to clickable chromatin employing CRISPR-dCas9. J. Am. Chem. Soc. 2020, 142, 13954-13965.

9. Walunj, M. B.; Srivatsan, S. G.* Nucleic acid conformation influences postsynthetic Suzuki-Miyaura labeling of oligonucleotides. Bioconjugate Chem. 2020, 31, 2513-2521.

Srivatsan Group

 

Chemical Biology: Nucleic Acid Chemistry, Biophysics, Self-assemblies

We use physical organic concepts to develop tools to assess structure, dynamics and function of nucleic acids in cell-free and complex cellular environments. In this direction, we have initiated two research programs. One involves the development of minimally perturbing and conformation-sensitive multi-app nucleoside probes for studying nucleic acids in real time by fluorescence, in 3D by X-ray crystallography and in cells by NMR. In the second program, we establish methods to label nucleic acids with variety of functionalities by using bioorthogonal chemistry like click and metal-catalyzed reactions. In parallel, we are also interested in developing multifunctional nucleolipid conjugates that self-assemble into nanofibres, nanotubes and gels. These assemblies show aggregation-induced fluorescence, self-sorting behavior and surface-switchable properties. Our research is multidisciplinary in nature involving synthetic organic chemistry, biophysics, molecular, cell and structural biology.

Our research in youtube: https://www.youtube.com/watch?v=7CFzZjauYl8

Srivatsan interview: https://www.youtube.com/watch?v=DLV32SCIuuo

Our efforts in COVID research: https://www.youtube.com/watch?v=KarLWR3CvzQ

 

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