LSSlab 

Publications (research articles) : 

Khan, S., Pradhan, S.J., Giraud, G., Bleicher, F., Paul, R., Merabet, S. and Shashidhara, L.S. (2021). A micro-evolutionary change in target binding sites as key determinant of Ultrabithorax function in Drosophila. Biorxiv. doi: https://doi.org/10.1101/2021.08.17.456507.

Monteiro, J.M. et al. Into the thirteenth Month: A Case Study on the Outbreak Analytics and Modeling the spread of SARS-CoV-2 Infection in Pune City, India (2021). MedRxiv. doi: https://doi.org/10.1101/2021.06.22.21259295.

Bogam, P., Joshi, J., Nagarkar, S., Jain, D., Gupte, N., Shashidhara, L.S., Monteiro, J.M. and Mave, V. (2021). The burden of COVID-19 and Case Fatality Rate in Pune India: An Analysis of First and Second Wave of the Pandemic. Burden of COVID-19 and case fatality rate in Pune, India: an analysis of the first and second wave of the pandemic,  International Journal of Infectious Diseases (IJID) Regions, 2, 2022, 74-81. https://doi.org/10.1016/j.ijregi.2021.12.006.

Rahman, A. and Shashidhara, L.S. (2021). Analyzing the influence of IL18 in regulation of YAP1 in breast oncogenesis using cBioportal. Cancer Reports. e1484. DOI: 10.1002/cnr2.1484.  

Chakraborty, A., Kumar, S., Shashidhara, L.S. and Taneja, A. (2021). Building Sustainable Societies through Purpose-Driven Universities: A Case Study from Ashoka University (India). Sustainability. 13, 7423. https://doi.org/10.3390/su13137423.

Busheri, L., Dixit, S., ..….., Shashidhara, L.S., Koppiker, C.B. and Kulkarni, M. “Breast Cancer Biobank from a Single Institutional cohort in an Urban Setting in India: Tumor Characteristics and Survival Outcomes.” Cancer Treatment and Research 28 (2021) 100409. https://doi.org/10.1016/j.ctarc.2021.100409.

Paul, R., Giraud, G., Domsch, K., Duffraisse, M., Marmigère, F., Khan, S., Lohmann, I., Stoks, R., Shashidhara, L.S. and Merabet, S. (2021). Hox dosage and the control of flight appendage morphology in insects. Nature Communications (12, 2892. https://doi.org/10.1038/s41467-021-23293-8.

Ghose, A., Bhattacharya, S., Karthikeyan, A.S., Kudale, A., Monteiro, J.M., Joshi, A., Medigeshi, G., Kang, G., Bal, V., Rath, S., Shashidhara, L.S., John, J., Chaudhuri, S. and Nagarkar, A. (2020). Community prevalence of antibodies to SARS-CoV-2 and correlates of protective immunity in five localities in an Indian metropolitan city. MedRxiv. doi: https://doi.org/10.1101/2020.11.17.20228155.

Vaid, P., Puntambekar, A., Banale, R., Reddy, R., Unde, R., Namewar, N., Kelkar, DA., Shashidhara, LS., Koppiker, CB. and Kulkarni, M (2020). Stromal Tumor Infiltrating Lymphocytes (sTILs) as a putative prognostic marker to identify a responsive subset of TNBC in an Indian Breast Cancer Cohort. MedRxiv. doi: https://doi.org/10.1101/2020.08.19.20177865. 

Chakladar M, Nair, MG., Prabhu, JS., Sridhar, TS., Kelkar, D., Kulkarni, M., Shashidhara, LS (2020). PTPN11 / SHP2 negatively regulates growth in breast epithelial cells: implications on tumorigenesis. BioRxIv. doi: https://doi.org/10.1101/2020.07.30.228445.    

Nagarkar, S., Wasnik, R., Govada, P., Cohen, S.M. and Shashidhara, L.S. (2020). Promoter proximal pausing limits Yki-induced tumorous growth in Drosophila. Genetics (early online)  https://doi.org/10.1534/genetics.120.303419         

Groth, C., Vaid, P., Khatpe, A., Prashali, N., Ahiya, A., Andrejeva, D., Chakladar, M., Nagarkar, S., Paul, R., Eichenlaub, T., Herranz, H., Sridhar, T.S., Cohen, S.M., and Shashidhara, L.S. (2020) Genome-wide RNAi screen for context-dependent tumor suppressors identified using in vivo models for neoplasia in Drosophila.G3: Genes, Genomes, Genetics (early online) https://doi.org/10.1534/g3.120.401545.

De las Heras, J.M., Garcia-Cortes, C., Foronda, D., Pastor-Pareja, J.C., Shashidhara, L.S. and Sanchez-Herrero, E. (2018). The Drosophila Hox gene Ultrabithorax controls appendage shape by regulating extracellular matrix dynamics. Development (doi: 10.1242/dev.161844). 

Shukla, J.P., Deshpande, G. and Shashidhara, L.S. (2017). Ataxin-2 binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis in Drosophila melanogaster. Development (doi: 10.1242/dev.140657).

Prasad, N.*, Tarikere, S.*, Khanale, D., Habib, F. and Shashidhara, L.S. (2016). A comparative genomic analysis of targets of Hox protein Ultrabithorax amongst distant insect species. Scientific Reports 6, 27885; doi: 10.1038/srep27885. * equal contribution. 

Singh, S., Sánchez-Herrero, E. and Shashidhara, L.S. (2015). Critical role for Fat/Hippo and IIS/Akt pathways downstream of Ultrabithorax during haltere specification in Drosophila. Mechanisms of Development 138 (Pt 2), 198-209.

Prasad, N. and Shashidhara, LS. (2015). Gliolectin positively regulates Notch signalling during wing-vein specification in Drosophila. International Journal of Developmental Biology 59, 187-94.

Subramaniam S, Sreenivas P, Cheedipudi S, Reddy VR, Shashidhara LS, Chilukoti RK, Mylavarapu M, Dhawan J. (2013). Distinct Transcriptional Networks in Quiescent Myoblasts: A Role for Wnt Signaling in Reversible vs. Irreversible Arrest. PLoS One 8, e65097. 

De Graeve,, F. M., Van de Bor, V., Ghiglione, C., Cerezo, D., Jouandin, P., Ueda, R., Shashidhara, L. S. and Noselli, S. (2012). Drosophila apc regulates delamination of invasive epithelial clusters. Developmental Biology 368, 76–85.

Agrawal, P., Habib, F., Yelagandula, R. and Shashidhara, L.S. (2011). Genome-level identification of targets of Hox protein Ultrabithorax in Drosophila: novel mechanisms for target selection. Scientific Reports 1, DOI: 10.1038/srep00205.

Tripura, CB, Prafulla-Chandrika, NN, Susmita, VNL, Noselli, S. and Shashidhara, LS (2011). A role for Odd-skipped in regulating JNK activity in the wing disc peripodial membrane during adult morphogenesis in Drosophila. International Journal of Developmental Biology 55, 583-590.

Usha, N. and Shashidhara, L.S. (2010). Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila. Developmental Biology341, 389–399.

Gurudatta, B.V., Shashidhara, L.S. and Parnaik., V.K. (2010). Lamin C and chromatin organization in Drosophila. J Genetics 89, 37-49.

Berger, C., Ramakrishnan, K., Myneni, S., Renner, S., Shashidhara, L.S. and Technau, G.M. (2010). Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function. Developmental Biology 337, 415–424. 

Ramakrishnan, K., Berger, C., Myneni, S., Technau, G.M. and Shashidhara, L.S. (2010). Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system. Mechanism of Development 127, 137-145.

Vyas, N., Goswami, D., Manonmani, A., Sharma, P., Ranganath, H.A., VijayRaghavan, K., Shashidhara, L.S., Sowdhamini, R. and Mayor, S. Nanoscale organization of Hh is essential for long range signaling. Cell 133, 1214-1227. (2008).

Gupta, R.K., Tripathi, R., Naidu, B.J., Srinivas, U.K. and Shashidhara, L.S. Cell cycle regulation by the pro-apoptotic gene Scotin. Cell Cycle 7, 2401-2408 (2008).

Ramesh Rao, P., Makhijani, K. and Shashidhara, L. S.Human APC sequesters b-catenin even in the absence of GSK-3b in a Drosophila model. Oncogene 27, 2488-2493. (2008).

Aritakula, A., Ramaswamy, A. and Shashidhara, L.S.Actin Cytoskeleton as a Putative Target of the Neem Limonoid Azadirachtin A. Insect Biochemistry and Molecular Biology 37, 627-634. (2007).

Makhijani, K., Chilukuri, K., Tamarisa, S. and Shashidhara, L.S.Modulation of Decapentaplegic gradient during haltere specification in Drosophila. Developmental Biology 302, 243-255. (2007).

S.K. Pallavi, Ramakrishnan Kannan and L.S. Shashidhara. (2006). Negative regulation of Egfr/Ras pathway by Ultrabithorax during haltere development in Drosophila. Developmental Biology 296, 340-352.

Mohit, P., Makhijani, K., Madhavi, M.B., Bharathi, V., Lal, A., Sirdesai, G., Reddy, V.R., Ramesh, P., Kannan, R., Dhawan, J. and Shashidhara, L.S. (2006). Modulation of AP and DV signalling pathways by the Homeotic gene Ultrabithorax during haltere development in Drosophila. Developmental Biology 291, 356-367.

Pallavi, S.K. and Shashidhara, L.S. (2005). Signaling interactions between squamous and columnar epithelia of Drosophila wing disc. J Cell Science 118, 3363-3370.

Ayyub, C., Sen, A., Gonsalves, F., Kishan, B., Bhandari, P., Shashidhara, L.S., Krishna S. and Rodrigues, V. (2005). Cullin-5 plays multiple roles in cell fate specification and synapse formation during Drosophila development. Developmental Dynamics 232, 865-75.

Berger, C., Pallavi, SK, Mohit, P., Shashidhara, L.S. and Technau, G.M. (2005). A critical role for Cyclin E in cell fate determination in the central nervous system of Drosophila. Nature Cell Biology 7, 56-62.

Bajpai, R., Sambrani, N., Stadelmayer, B. and Shashidhara, L.S. (2004). Identification of a novel target of D/V signaling in Drosophila wing disc: Wg-independent function of the organizer. Mechanism of Development (GEP). 5, 113-121.

Bharathi, V., Bajpai, R., Pallavi, S.K., Emerald, B.S. and Shashidhara, L.S. (2004). Genetic characterization of Drosophila homologue of coronin. J Cell Science 117, 1911-1922.

Bajpai, R., Makhijani, K., Ramesh Rao, P. and Shashidhara, L. S. (2004) Drosophila Twins regulates Armadillo levels in response to Wg/Wnt signal. Development 131, 1007-1016.

Pallavi, S.K. and Shashidhara, L.S. (2003). EGFR/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs. Development 130, 4931-4941.

Mohit, P., Bajpai, R. and Shashidhara, L.S. (2003) Regulation of Wingless and Vestigial expression in wing and haltere discs of Drosophila. Development 130, 1537-1547.

Bhandari, P and Shashidhara, L.S. (2001). Studies on human colon cancer gene APC by targeted expression in Drosophila. Oncogene 20, 6871-6880.

Emerald, B. S., and Shashidhara, L. S. (2000). Negative regulation of Ultrabithorax expression by engrailed is required for the proper specification of wing and haltere development in Drosophila. J Genet. 79, 61-70. 

Shashidhara, L. S., Agrawal, N., Bajpai, R., Bharathi, V. and Sinha, P. (1999). Negative Regulation of Dorso-Ventral Signaling by the Homeotic Gene Ultrabithorax during Haltere Development in Drosophila. Dev. Biol. 212, 491-502.

Bhojwani, J., Shashidhara, L.S. and Sinha, P. (1997). Requirement for teashirtDrosophila  Function during Cell Fate Specification in Developing Head Structures in . Dev. Genes and Evol. (formerly Roux's Archives in Dev. Biol.) 207, 137-146.

Deshpande, N., Chopra, A., Rangarajan, A., Shashidhara, L. S., Rodrigues,
V. and Krishna, S. (1997). The Human Transcription Enhancer Factor-1, TEF-1, Can Substitute for Drosophila scalloped during Wing-blade Development. J. Biol. Chem. 272, 10664-10688.

Roy, S., Shashidhara, L. S. and VijayRaghavan, K. (1997). Muscles in the Drosophila Second Thoracic Segment are Patterned Independently of Autonomous Homeotic Gene Function. Current Biology 7, 222-227.

Brookman, J.J., Toosy, A.T., Shashidhara, L.S. and White, R.A.H. (1992). 412 Retrotransposon is Expressed in a Subset of Mesoderm in Drosophila. Development 116: 1185-1192.

Shashidhara, L.S., Lim, S-H., Shackleton, J.K., Robinson, C. and Smith, A.G. (1991). Protein Targeting Across the 3 Membranes of the Euglena Chloroplast Envelope. J.Biol.Chem. 267: 12885-12891.

Shashidhara, L.S. and Smith, A.G. (1991). Expression and Subcellular Location of the Tetrapyrrole Synthesis Enzyme Porphobilinogen Deaminase in Light-grown Euglena gracilis and three nonchlorophyllous cell lines. Proc. Natl. Acad. Sci. USA. 88: 63-67.

Shashidhara, L.S., Patil, S.S., Goud, J.V., Parameshwarappa, R., Rao, A. and Basarkar, P.W. (1989). Induced Variation in Derived F1s for Quality Attributes in Sorghum bicolor  (L.) Moench. J. Nuclear Agric. Biol. 18: 175-178.

Shashidhara, L.S., Patil, S.S., Goud, J.V. and Parameshwarappa, R. (1990). MMS and Gamma Ray Induced Variability for Different Traits in M1, M2 and M3 Generations of Sorghum. J. Maharashtra Agric.Univ. 15 (1): 20-23.

 

Reviews / Book Chapter

1. Kulkarni, A., Kelkar, D.A., Parikh, N., Shashidhara, L.S., Koppiker, C.B. and Kulkarni, M. (2020). Meta-analysis of prevalence of Triple-Negative breast cancer and its clinical features at incidence in Indian patients with breast cancer. JCO Global Oncology2020 :6, 1052-106.    
   
2. Khan, S., Dilsha, C. and Shadhidhara, L.S. (2020). Haltere development in D. melanogaster: implications for the evolution of appendage size, shape and function. Int. J. Dev. Biol. 64: 169 – 175. doi: 10.1387/ijdb.190133LS.    
   
3. Agrawal, P., and Shashidhara, L.S. (2014). ChIP for Hox proteins from Drosophila imaginal discs. In Methods in Enzymology, Humana Press, Springer Publications.
4. Ghose, A. and Shashidhara, L.S. (2011). Cyclin beyond the cell cycle: new partners at the synapse. Developmental Cell. 21, 601-12.
5. Berger, C., Pallavi, SK, Mohit, P., Shashidhara, L.S. and Technau, G.M. (2005). CyclinE acts under the control of Hox-genes as a cell-fate determinant in the developing central nervous system. Cell Cycle. 4, 422-5.
6. Krishna, S., Shashidhara L.S., Deshpande, N., Daniel, B. and Tergaonkar, V. (1996). In vivo Approaches to Studying Human Papillomaviruses: In the "Current Developments in Animal Virology", S Jameel and E K Wagner (eds), Oxford and IBH Publishing Co. New Delhi.  pp 223-230.
7. White, R.A.H., Brookman, J.J., Gould, A.P., Meadows, L.A., Shashidhara, L.S., Strutt, D.I., and Weaver, T.A. (1992). Targets of Homeotic Gene Regulation in Drosophila. J. Cell Sci. 16 (S): 53-60.

General/popular Science Articles, books and Policy Documents:

1. Commissioned and Edited, an anthology on Impact of Science in Independent India in 2017-18: http://www.insaindia.res.in/pdf/Book_Release_ISTI.pdf.
2. Co-author: Scientific advancements in Independent India. Current Science, Vol. 112, 10 January 2017. http://www.currentscience.ac.in/Volumes/112/01/0015.pdf.
3. Co-author: Gender-sensitization in Indian science:  Attitudes and Action items. Current Science (in press).
4. Guest Editorial: “Who are people of Genius?” Current Science, Vol. 107, 10 September 2014. http://www.currentscience.ac.in/Volumes/107/05/0731.pdf.
5. Convener, Vision Group of INSA which drafted a Vision document for Indian Science in 2010: http://insaindia.res.in/pdf/INSA_Vision_2010.pdf.