|
Krishna N Ganesh
Professor and Coordinator, Chemistry
Director, IISER Pune
J C Bose Fellow (DST), NCL Pune
E-mail:
director at iiserpune.ac.in
kn.ganesh at iiserpune.ac.in
Website: http://www.iiserpune.ac.in/~kn.ganesh
OFFICE :
Indian Institute of Science Education and Research,
Main Building, First Floor,
Dr. Homi Bhabha Road, Pashan,
Pune 411008, India
|
|
Education
and
previous work experience
1967-1972
B.Sc and M.Sc (Bangalore University)
1972-1977, Ph.D (Delhi University)
1977-1980, Ph.D (Cambridge University, UK)
1981-1987, Scientist, Centre for Cellular and Molecular Biology, Hyderabad
1987-2006, Scientist, National Chemical Laboratory, Pune
1994-2006, Head, Division of Organic Chemistry (Synthesis), NCL,
Pune
July 2006 - present: Professor and Director, IISER Pune
Award
and Honors
1985:
Science Academy Medal for Young Scientists, Indian National Science
Academy, New Delhi.
1993: Fellow, Indian Academy of Sciences, Bangalore
1998: CSIR Bhatnagar Award in Chemical Sciences
1999: Fellow, Indian National Science Academy, Delhi
2004: Silver Medal, Chemical Research Society of India, Bangalore
2005: TWAS Prize in Chemical Sciences
2005: Elected Secretary, Biomolecular Chemistry Division, Sub
Committee, IUPAC
2006: JC Bose Fellowship, Department of Science and Technology, India
2006: Fellow, Academy of Sciences for Developing World (TWAS), Trieste
2014: SASTRA CNR Rao Award in Chemistry
2015: HK Firodia Award in Chemical Sciences
2016: National Researcher Award in Nanoscience and Technology, DST, New Delhi
Research
interests
Biomolecular chemistry of nucleic acids, peptides and lipids; drug development; antisense/antigene technology; DNA diagnostics and nanotechnology; chemistry education
Recent
Publications
1. Mahesh V. Sonar and Krishna N. Ganesh, Switching structures by H-bond rearrangement: Transformation of β-structure in poly-4S-Aminoproline to PPII conformation, Org. Lett, 2010, 12, 5406-5409.
2. Roopa Mitra and Krishna Ganesh, PNAs grafted with (a/g, R/S)-aminomethylene pendants: Regio- and stereospecific effects on DNA binding and improved cell uptake, Chem. Commun., 2010, 12, 5390-5393.
3. Amit N. Patwa, Rajesh G. Gonnade, Vaijayanti A. Kumar, Mohan M. Bhadbhade, Krishna N. Ganesh, Ferrocene–bis(thymine/uracil) conjugates: Base pairing directed, spacer dependent self assembly and supramolecular packing, J. Org. Chem, 2010, 75, 8705-8708.
4. Nagendra K. Sharma and Krishna N. Ganesh, Enhanced stability of G-Tetraplexes from Conformationally Constrained aep-PNA backbone, Organic Biomolecular Chemistry, 2011, 9, 725-729.
5. A Gourishankar and Krishna N Ganesh (α,α-dimethyl)glycyl (dmg) PNAs: achiral PNA analogs that form stronger hybrids with cDNA relative to isosequential RNA, Art DNA, PNA:XNA, 2012, 3, 1-9.
6. M. Umashankara, Manaswini Nanda, Mahesh Sonar, and Krishna N. Ganesh, 4(R/S)-Amino/Guanidino-substituted Proline Peptides: Design, Synthesis and DNA Transfection Properties, Chimia, 2012, 66, 936–940.
7. Manaswini Nanda and Krishna N. Ganesh, 4(R/S)-Guanidinylprolyl Collagen Peptides: On-Resin Synthesis, Complexation with Plasmid DNA, and the Role of Peptides in Enhancement of Transfection, J. Org. Chem. 2012, 77, 4131−4135.
8. Krishna N Ganesh and Yamuna Krishnan, Nucleic Acids − Chemistry and Applications. J. Org. Chem. 2013, 78, 12283−12287.
9. Deepak R. Jain and Krishna N. Ganesh, Clickable Cγ‑Azido(methylene/butylene) Peptide Nucleic Acids and Their Clicked Fluorescent Derivatives: Synthesis, DNA Hybridization Properties, and Cell Penetration Studies. J. Org. Chem. 2014, 79, 6708−6714.
10. Deepak Ramesh Jain, Libi Anandi V., Mayurika Lahiri, and Krishna N. Ganesh, Influence of Pendant Chiral C#-(alkylideneamino/guanidino) Cationic Sidechains of PNA Backbone on Hybridization with Complementary DNA/RNA and Cell Permeability, J. Org. Chem. 2014, 79, 9567-9577.
11. Deepak R. Jain and Krishna N. Ganesh, Clickable Cγ‑Azido(methylene/butylene) Peptide Nucleic Acids and Their Clicked Fluorescent Derivatives: Synthesis, DNA Hybridization Properties, and Cell Penetration Studies. J. Org. Chem. 2014, 79, 6708−6714.
12. Deepak Ramesh Jain, Libi Anandi V., Mayurika Lahiri, and Krishna N. Ganesh, Influence of Pendant Chiral Cγ-(alkylideneamino/guanidino) Cationic Sidechains of PNA Backbone on Hybridization with Complementary DNA/RNA and Cell Permeability, J. Org. Chem. 2014, 79, 9567-9577.
13. Muddegowda Umashankara, Mahesh V. Sonar, Nitin D. Bansode and Krishna N. Ganesh, Orchestration of Structural, Stereoelectronic, and Hydrogen-Bonding Effects in Stabilizing Triplexes from Engineered Chimeric Collagen Peptides (ProX‑ ProY‑ Gly)6 Incorporating 4(R/S)‑Aminoproline, J. Org. Chem. 2015, 80, 8552-8560.
14. Satheesh Ellipilli and Krishna N. Ganesh, Fluorous Peptide Nucleic Acids: PNA Analogues with Fluorine in Backbone (γ-CF2-apg-PNA) Enhance Cellular Uptake, J. Org. Chem. 2015, 80, 9185-9191.
15. Satheesh Ellipilli, Raghavendra Vasudeva Murthy and Krishna N. Ganesh, Perfluoroalkylchain conjugation as a new tactic for enhancing cell permeability of peptide nucleic acids (PNAs) via reducing the nanoparticle size, Chem Commun, 2016, 52, 521-524.
16. Nitin D. Bansode, Mahesh V. Sonar and Krishna N. Ganesh, A nanofiber assembly directed by the non-classical antiparallel β-structure from 4S-(OH) proline polypeptide, Chem. Commun., 2016, DOI: 10.1039/c6cc00838k
Patents
1. An enzymatic process for the preparation of optically pure diols, S.B.desai, N.P.Argade and K.N.Ganesh, Indian Patent, 2738/DEL/96
2. A new process for the preparation of (±)–threo-ethyl 3-(4-methoxyphenyl)-2,3-diacetoxy propionate, S. B. Desai, N.P. Argade and K. N. Ganesh, Indian Patent, 2739/DEL/96
3. Method for the hydrophobisation of DNA molecules, M. Sastry, A. Kumar, V. Ramakrishnan and K.N.Ganesh, U.S.Patent NF 304/01
4. Chiral, charged peptide nucleic acid oligomers from cyclic monomers, V. A. Kumar, M. D’Costa and K. N. Ganesh, US patent 7579563, (2009)
|
|